Nagarajan Manikandan is specializing in the intricate mechanisms governing the characteristics and function of blood vessels in the context of cardiovascular and metabolic diseases. His research utilizes animal models, isolated vessels, and cultured cells to uncover the underlying mechanisms that influence vascular characteristics. He employs a multidisciplinary approach, integrating cutting-edge techniques such as Ultrasound Imaging, Confocal/Multiphoton Microscopy, Immunohistochemistry, Western blotting, Proteomics. His work is at the forefront of vascular research, aiming to elucidate the complex biological processes that contribute to the development and progression of cardiovascular and metabolic diseases.