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Dr. Domeier is the Principal Investigator of the Cardiac Cell Physiology laboratory, which investigates pathological alterations in cardiac muscle cell calcium handling in diseases including heart failure, muscular dystrophy, diabetes, genetic cardiomyopathy, and arrhythmia. With each heartbeat, calcium in the cardiac muscle cell cycles dramatically, changing from very low levels during diastole to high levels during systole. In the normal heart these calcium signals exhibit precise timing, which orchestrates the coordinated contraction of all muscle cells and ensures proper pumping of blood. During heart disease muscle cells are unable to properly regulate calcium which leads to cellular contractile dysfunction, muscle cell damage, and electrophysiological abnormalities. In patients, these cellular findings manifest as cardiac failure, cardiac arrhythmia, and sudden death. The laboratory uses innovative approaches to examine when and where calcium changes within the muscle cell, with the overall goal of designing targeted therapeutic approaches to treat patients with cardiovascular disease.

https://medicine.missouri.edu/faculty/timothy-l-domeier-phd

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