Our laboratory focuses on the cardiovascular and respiratory systems. These vital systems operate to keep our bodies within “normal” physiological limits to preserve homeostasis. When challenged with low environmental oxygen (hypoxia) levels respiration, blood pressure and heart rate compensate to maintain arterial blood gas levels. This can happen during high altitude assent or disease states such as sleep apnea. Long term hypoxic challenges result not only in physiological changes but also gene changes. Determining these mechanisms during health and disease is the focus of the laboratory.