Dr. Chen has a broad research interest in vascular biology. He has been studying molecular mechanisms underlying the development of a number of vascular diseases including abdominal aortic aneurysm, atherosclerosis, hypertension, restenosis and vascular remodeling following vascular injury such as angioplasty, etc. His efforts have been largely directed to investigate vascular smooth muscle phenotypic modulation during artery wall remodeling in pathological conditions. Dr. Chen also studies vascular inflammation, endothelial dysfunction, and metabolic disorders including obesity and fatty liver diseases. His laboratory uses a variety of molecular and cellular technology as well as animal models and human biopsies to address fundamental questions in disease development.